For skincare products that seem to be the same strength, why are they so different?

Dr. Irwin: What is the change in between Refissa tretinoin cream USP .05% vs Perrigo’s tretinoin cream USP .05%? I have been employing Refissa for yrs, but now I have a trouble acquiring it due to a backlog. I speculate if I can use Perrigo’s tretinoin product USP .05% instead? Lots of many thanks Amy.

Some times I believe we all require a diploma in chemistry to truly recognize skincare product labels. I enjoy your issue simply because it definitely gets back to that problem.

To answer your query, if you really adore Refissa (tretinoin .05%), I question you are going to like the Perrigo tretinion because the base is so a great deal thinner and formulated far more for oily pores and skin. Refissa had an virtually ointment-like base, and was great for dry skin. For all those of you who never know, tretinion is just a concentrated model of retinol.

There are a lot of tretinoin solutions on the marketplace, and they arrive in gels, lotions, and creams. The traces amongst these distinctive motor vehicles are normally blurred while. You may possibly have a lotion-like gel or a pretty thick lotion that works far more like a cream. The same is real for tons of other solutions.

Does it truly subject? Obtaining watched clients and myself struggle to change a favored now discontinued product or service, I consider it does. Why?  Go through on.

Why does the foundation or automobile of the product or service make these kinds of a change:

  • If you want a product that functions for dry pores and skin, look for the major 5-6 components to be matters like squalene, normal oils, shea butter, and even petrolatum.
  • If you want a product that is effective for oilier pores and skin, then seem for goods that have additional hyaluronic acid, non annoying alcohols, aloe vera and identical in the top 5-6 elements listed.
  • The components most very likely to trigger pores and skin irritation are preservatives, fragrances, propylene glycol, lanolin and some alcohols.
  • The base has an effect on the bioavailability of the lively component too. That tretinoin .05% may perhaps be rather much better, or weaker, based on what it is set in there’s genuinely no way to notify that as a shopper in advance of time.
  • Organic oils and dry oils are all the rage now, but they can clog pores in prone persons irrespective of the promoting.
  • Lotions are it’s possible the hardest to appraise with no essentially obtaining them for the reason that some are extra gel-like. Some are light-weight and take up effortlessly, some mid-pounds, and some are extremely dense and extra occlusive.
  • Do samples enable? They can assist you tell whether or not you are allergic to it, if the fragrance will work for you, and if the regularity is ideal for you. Other than that, they aren’t really beneficial. It will take 30-90 times to see if a merchandise really will make a change in the good quality of your pores and skin. We all have drawers of them although, and I’d vote for a thoroughly clean out and dump session twice a calendar year.


Hope this can help!
Dr. Brandith Irwin, MD
Founder of SkinTour & MadisonMD Skincare
Abide by my skin ideas and travels on Instagram!